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Lower Cost Than Drugs...
Zona PLUS offers a significant savings over the average prescribed drug. A look at the numbers proves that for most people, Zona PLUS will pay for itself within the first year....MORE
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Medical Research

Published medical studies, university research reports and numerous white papers support the science behind Zona PLUSTM. Each of these independent reviews discusses the challenges and solutions associated with hypertension and they have arrived at the same conclusions—Zona PLUSTM can significantly lower high blood pressure by:

  • Decreasing sympathetic modulation and increases parasympathetic modulation
  • Increasing Nitric Oxide production
  • Improving antioxidant levels
To learn more about the effects of isometric exercise on hypertension and review the test results of Zona PLUSTM, click on the links below.
Clinical Documents
"Acute Vascular Responses to Isometric Handgrip Exercise and the Effects of Training in Persons Medicated for Hypertension" Departments of Kinesiology and Medicine, McMaster University, April, 2006
"Short-term isometric exercise reduces systolic blood pressure in hypertensive adults: Possible role of reactive oxygen species" International Journal of Cardiology-Pre Publication Article, July 2005
"Isometric handgrip training reduces arterial pressure at rest without changes in sympathetic nerve activity" AJP-Heart, 279:245-249, 2000
"The effects of isometric excercies training on resting blood pressure and othostatic tolerance in humans"Experimental Physiology (2002) 87.4, 507-515
"Isometric Training Lowers Resting Blood Pressure and Modulates Autonomic Control"   Medicine & Science in Sports & Exercise, 35(2):251-256, February 2003.
"Isometric exercise training lowers resting blood pressure" Medicine & Science in Sports and Exercise, 24(7): 749-754, July 1992.
"Isometric handgrip training improves blood pressure and endothelial function in persons medicated for hypertension" The APS Intersociety Meeting: Integrative MeetingAbstracts of Invited and Contributed Presentation
"The effect of isometric arm of leg exercise on resting blood pressure and arterial distensibility in persons medicated for hypertension" The APS Intersociety Meeting: Integrative MeetingAbstracts of Invited and Contributed Presentation
"Cardiovascular benefits of controlled isometric training may be due to an Improvement in endothelial function via up regulation of nitric oxide synthase through shear stress induced transcriptional mechanisms" D.W. Ferguson, PhD.
"Regular isometric handgrip training lowers and controls blood pressure in hypertensive patients; 4 one year cases" Independent Evaluation, Harry I. Geisberg, M.D.